Christian Grimm, Prof. Dr. Dr.

CV - Lebenslauf

Publikationen

Key publications

- Martucci LL, Launay JM, Kawakami N, Sicard C, Desvignes N, Dakouane-Giudicelli M, Spix B, Têtu M, Gilmaire F-O, Paulcan S, Callebert J, Vaillend C, Bracher F, Grimm C, Fossier P, de la Porte S, Sakamoto S, Morris J, Galione A, Granon S, Cancela J-M: Endo-lysosomal two-pore channels regulate social behaviour by controlling oxytocin and vasopressin secretion. PNAS accepted, in press

- Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Do AND, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M: CLN3 is required for the efflux of glycerophosphodiesters from lysosomes. Nature 2022.Sep 21. doi: 10.1038/s41586-022-05221-y.

- Scotto Rosato A*, Krogsaeter E*, Jaślan D, Abrahamian C, Montefusco S, Soldati C, Spix B, Böck J, Pizzo, MT, Grieco, G, Wyatt A, Wünkhaus D, Passon M, Stieglitz M, Keller M, Hermey G, Markmann S, Gruber-Schoffnegger D, Cotman S, Johannes L, Crusius D, Boehm U, Wahl-Schott C, Biel M, Bracher F, De Leonibus, E, Polishchuk E, Medina DL, Paquet D, Grimm C^#: TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1 and Batten disease. EMBO Mol Med 5:e15377, 2022.

- Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE, Abrahamian C, Keller M, Hartmann J, Scotto Rosato A, Weiden E-M, Bracher F, Yule DI, Grimm C^#, Patel, S: Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. Nature Commun 13(1):4481, 2022.

- Spix B, Butz ES, Chen C-C, Scotto Rosato A, Tang, R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günes Günsel G, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim AÖ, Biel, M, Grimm C^#: Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nature Commun 13(1):318, 2022.

- Soldati C, Lopez-Fabuel I, Wanderlingh LG, Macia MG, Monfregola J, Esposito A, Napolitano G, Guevara-Ferrer M, Scotto Rosato A, Krogsaeter EK, Paquet D, Grimm C, Montefusco S, Braulke T, Storch S, Mole SE, De Matteis MA, Ballabio A, Lopes Sampaio J, McKay T, Johannes L, Bolanos JP, Medina D: Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype. EMBO Mol Med 13(10):e13742, 2021.

- Chen C-C, Krogsaeter E, Butz E, Li Y, Puertollano R, Wahl-Schott C, Biel M, Grimm C^#: TRPML2 is an osmo-/mechano-sensitive cation channel in endolysosomal organelles. Science Adv. 6(46):eabb5064, 2020.

- Arlt E, Fraticelli M, Tsvilovskyy V, Nadolni W, Breit A, O’Neill TJ, Resenberger S, Wennemuth G, Wahl-Schott C, Biel M, Grimm C, Freichel M, Gudermann T, Klugbauer N, Boekhoff I, Zierler S: TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity. PNAS 13:201920122, 2020.

- Scotto Rosato A, Montefusco S, Soldati C, Di Paola S, Capuozzo A, Monfregola J, Polishchuk E, Amabile A, Grimm C, Lombardo A, De Matteis MA, Ballabio A, Medina DL: TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway. Nature Commun 10:5630, 2019.

- Goodridge J, Jacobs B, Saetersmoen M, Clement D, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Thune Wiiger M, Louch WE, Heggernes Ask F, Liu LL, Yi Sheng Oei V, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ: TRPML1-mediated modulation of dense-core granules determines functional potential in NK cells. Nature Commun 10:514, 2019.

- Villella VR, Venerando A, Cozza G, Esposito S, Ferrari E, Monzani R, Spinella MC, Oikonomou V, Renga G, Tosco A, Rossin F, Guido S, Bear CE, Silano M, Garaci E, Chao YK, Grimm C, Luciani A, Romani L, Piacentini M, Raia V, Kroemer G & Maiuri L: A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J 38.pii: e100101, 2019.
See also comment by Shmuel Muallem, NIH: https://www.ncbi.nlm.nih.gov/pubmed/30573671

- Chao Y-K, Schludi V, Chen C-C, Butz E, Nguyen P, Müller M, Krüger J, Kammerbauer C, Vollmar A, Berking C, Biel M, Wahl-Schott C, Grimm C^#: TPC2 polymorphisms associated with a human hair pigmentation phenotype result in gain of channel function by independent mechanisms. PNAS 114:E8595-E8602, 2017.

- Chen C-C, Chunlei C, Fenske S, Butz E, Chao Y-K, Biel M, Ren D, Wahl-Schott C, Grimm C^#: Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nature Protoc 12:1639-1658, 2017.

- Ruas M, Davis LC, Chen C-C, Morgan AJ, Chuang K-T, Walseth TF, Grimm C, Garnham C, Powell T, Biel M, Wahl-Schott C, Parrington J, Galione A: Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J 34:1743-1758, 2015.
See also comment by Jentsch et al., MDC, Berlin: https://www.ncbi.nlm.nih.gov/pubmed/26022292

- Sakurai Y, Kolokoltsov AA, Chen C-C, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA: Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment, Science 347:995-998, 2015.
See also comment by Falzarano & Feldmann: https://www.ncbi.nlm.nih.gov/pubmed/25722396

- Chen C-C, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C^#: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Commun 5:4681, 2014.

- Grimm C, Holdt LM, Chen C-C, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C: High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature Commun 5:4699, 2014.

- Aneiros E, Cao L, Papakosta M, Stevens EB, Phillips SC, Grimm C^#: Biophysical and molecular basis of TRPV1 proton gating. EMBO J 30:994-1002, 2011.

- Grimm C, Cuajungco MP, van Aken AFJ, Schnee M, Jörs S, Kros CJ, Ricci AJ, Heller S: A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. PNAS 104:19583-19588, 2007.

* authors contributed equally; # corresponding or shared corresponding author