Publikationen
Peer-Reviewed Publications
• The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis. Nadolni W, Zierler S. Cells. 2018. doi: 10.3390/cells7080109. (Review)
• TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. Arterioscler Thromb Vasc Biol. 2018. doi: 10.1161/ATVBAHA.117.310391.
• TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Zierler S. Nature Communications. 2017. doi: 10.1038/s41467-017-01960-z.
• TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP. Ferioli S, Zierler S, Zaißerer J, Schredelseker J, Gudermann T, Chubanov V. Scientific Reports. 2017. doi: 10.1038/s41598-017-08144-1.
• TRPM channels as potential therapeutic targets against pro-inflammatory diseases. Zierler S, Hampe S, Nadolni W. Cell Calcium. 2017. doi: 10.1016/j.ceca.2017.05.002. (Review).
• Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Elife. 2016. doi: 10.7554/eLife.20914.
• Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Nature Communications. 2016. doi: 10.1038/ncomms11097.
• Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. Schäfer S, Ferioli S, Hofmann T, Zierler S, Gudermann T, Chubanov V. Pflugers Archive. 2016. doi: 10.1007/s00424-015-1772-7.
• TRPM7 kinase activity regulates murine mast cell degranulation. Zierler S, Sumoza-Toledo A, Suzuki S, Dúill FÓ, Ryazanova LV, Penner R, Ryazanov AG, Fleig A. J Physiol. 2016. doi: 10.1113/JP271564.
• The IP3-R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa. Borth H, Weber N, Meyer D, Wartenberg A, Arlt E, Zierler S, Breit A, Wennemuth G, Gudermann T, Boekhoff I. J Cell Physiol. 2016. doi: 10.1002/jcp.25209.
• NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, Borth H, Zierler S, Wennemuth G, Breit A, Biel M, Wahl-Schott C, Gudermann T, Klugbauer N, Boekhoff I. Mol Biol Cell. 2014. doi: 10.1091/mbc.E13-09-0523.
• Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade. Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH. Leukemia. 2014. doi: 10.1038/leu.2014.37.
• Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways. Solinski HJ, Zierler S, Gudermann T, Breit A. J Biol Chem. 2012. doi: 10.1074/jbc.M112.408617.
• Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. Zierler S, Yao G, Zhang Z, Kuo WC, Pörzgen P, Penner R, Horgen FD, Fleig A. J Biol Chem. 2011. doi: 10.1074/jbc.M111.264341.
• A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. Lis A, Zierler S, Peinelt C, Fleig A, Penner R. J Gen Physiol. 2010. doi: 10.1085/jgp.201010484.
• TRPM7 is essential for Mg(2+) homeostasis in mammals. Ryazanova LV, Rondon LJ, Zierler S, Hu Z, Galli J, Yamaguchi TP, Mazur A, Fleig A, Ryazanov AG. Nature Communications. 2010. doi: 10.1038/ncomms1108.
• Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells. Sacha B, Zierler S, Lehnardt S, Weber JR, Kerschbaum HH. J Neurosci Res. 2008. doi: 10.1002/jnr.21811.
• Chloride influx provokes lamellipodium formation in microglial cells. Zierler S, Frei E, Grissmer S, Kerschbaum HH. Cell Physiol Biochem. 2008. doi: 10.1159/000113747.
• Blockade of chloride channels suppresses engulfment of microspheres in the microglial cell line, BV-2. Furtner T, Zierler S, Kerschbaum HH. Brain Res. 2007. doi: 10.1016/j.brainres.2007.09.057.
• cAMP mediates ammonia-induced programmed cell death in the microglial cell line BV-2. Svoboda N, Zierler S, Kerschbaum HH. Eur J Neurosci. 2007. doi: 10.1111/j.1460-9568.2007.05452.x.
• An artificial three-dimensional matrix promotes ramification in the microglial cell-line, BV-2. Pöttler M, Zierler S, Kerschbaum HH. Neurosci Lett. 2006. doi: 10.1016/j.neulet.2006.09.082.
• Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2. Zierler S, Klein B, Furtner T, Bresgen N, Lütz-Meindl U, Kerschbaum HH. Brain Res. 2006. doi: 10.1016/j.brainres.2006.08.122.
• Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2. Zierler S, Kerschbaum HH. Brain Res. 2005. doi: 10.1016/j.brainres.2005.01.086.