Publikationen
Alle Literaturangaben zu finden bei Pubmed
Originalarbeiten
Nicke A, Bäumert HG, Rettinger J, Eichele A, Lambrecht G, Mutschler, E, Schmalzing G (1998)
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.
EMBO J, 17:3016-3028
Nicke A, Rettinger J, Mutschler E, Schmalzing G (1999)
Blue native PAGE as a useful method for the analysis of the assembly of distinct combinations of nicotinic acetylcholine receptor subunits.
J. Recept. Sign. Transduc. Res, 19:493-507
Griffon N, Büttner C, Nicke A, Kuhse J, Schmalzing G, Betz H (1999)
Molecular determinants of glycine receptor subunit assembly.
EMBO J, 18:4711-4721
Horiuchi M*, Nicke A*, Gomeza J, Ashrafi A, Schmalzing G, Betz H (2001)
Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes.
Proc. Natl. Acad. Sci. USA, 98:1448-1453
Nicke A, Rettinger J, Schmalzing G (2003)
Monomeric and dimeric byproducts are the principal functional elements of higher order P2X1 concatamers.
Mol. Pharmacol, 63:243-252
Nicke A, Loughnan M, Millard E, Alewood PF, Adams DJ, Daly N, Craik DJ, Lewis, RJ (2003)
Isolation, structure, and activity of GID, a novel 4/7-conotoxin with an additional N-terminal sequence.
J. Biol. Chem, 278:3137-3144
Sadtler S, Laube B, Lasub A, Nicke A, Betz H, Schmalzing G (2003)
A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor 1 subunit.
J. Biol. Chem, 278:16782-16790
Nicke A, Samochocki M, Loughnan ML, Bansal P, Maelicke A, Lewis, RJ (2003)
-Conotoxins EpI and AuIB switch subtype selectivity and activity in native vs oocyte-expressed nicotinic acetylcholine Rezeptors.
FEBS Lett, 554:219-223
Loughnan ML*, Nicke A*, Jones A, Adams DJ, Alewood PF, Lewis, RJ (2004)
Chemical and functional identification and characterization of novel sulfated -conotoxins from the cone snail Conus anemone.
J. Med. Chem, 47:1234-1241
Dutertre S, Nicke A, Tyndall JDA, Lewis RJ (2004)
Determination of -conotoxin binding modes on neuronal nicotinic acetylcholine receptors
J. Mol. Recognition, 17:339-347
Nicke A*, Thurau H*, Sadtler S, Rettinger J, Schmalzing G (2004)
Assembly of nicotinic 7 subunits in Xenopus oocytes is partially arrested at the tetramer level.
FEBS Lett, 575:52-58
Nicke A*, Kerschensteiner D*, Soto F (2005)
Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunits.
J. Neurochem, 92:925-933
Grudzinska J, Schemm R, Haeger S, Nicke A, Schmalzing G, Betz H, Laube B (2005)
The subunit determines the ligand binding properties of synaptic glycine receptors.
Neuron, 45:727-739
Dutertre S*, Nicke A*, Lewis RJ (2005)
2 subunit contribution to 4/7 -conotoxin binding to the nicotinic acetylcholine receptor.
J. Biol. Chem, 280:30460-30468
Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis, RJ (2006)
Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum.
J. Biol. Chem, 281:24745-55
Madry C, Mesic I, Bartholomäus I, Nicke A, Betz H, Laube B (2007)
Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function
Biochem. Biophys. Res. Commun, 354:102-108
Marquez-Klaka B, Rettinger J, Bhargava Y, Eisele T, Nicke A (2007)
Identification of an inter-subunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor.
J. Neurosci, 27:1456-1466
Dutertre S*, Ulens C*, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ (2007)
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
EMBO J, 26:3858-67
Reeger R, Nicke A, Markovich D (2007)
Quaternary structure and apical membrane sorting of the mammalian NaSi-1 sulfate transporter in renal cell lines.
Int. J. Biochem. Cell Biol, 39:2240-51
Bartholomaeus I, Milan-Lobo L, Nicke A, Dutertre S, Hastrup H, Jha A, Gether U, Sitte HH, Betz H, Eulenburg V (2008)
Glycine transporter dimers: Evidence for occurrence in the plasma membrane.
J. Biol. Chem, 283:10978-91
Nicke A (2008)
Homotrimeric complexes are the dominant assembly state of P2X7 subunits in native tissues.
Biochem. Biophys. Res. Commun, 377:803-8
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. (2009)
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues.
J. Biol. Chem, 284:4944-51
Marquez-Klaka B, Rettinger J, Nicke A (2009)
Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X Rezeptors.
Eur. Biophys. J, 38:329-38
Loughnan ML, Nicke A, Lawrence N, Lewis RJ (2009)
Novel D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily.
Biochemistry, 48:3717-29
Kauferstein S, Kendel Y, Nicke A, Coronas FIV, Possani LD, Favreau P, Krizaj I, Wunder C, Kauert G, Mebs D (2009)
New conotoxins of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine Rezeptors.
Toxicon, 54:295-301
Nicke A, Kuan YH, Masin M, Rettinger J, Marquez-Klaka B, Bender O, Gorecki D, Murrell-Lagnado R, Soto F (2009)
A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 KO mice.
J. Biol. Chem, 284:25813-22
Kauferstein S, Porth C, Kendel Y, Wunder C, Nicke A, Kordis D, Favreau P, Koua D, Stöcklin R, Mebs D. (2011)
Venomic study on cone snails (Conus spp.) from South-Africa.
Toxicon, 57:28-34
Lörinczi É, Bhargava Y*, Marino SF*, Taly A*, Kaczmarek-Hájek K, Barrantes-Freer A, Dutertre S, Grutter T, Rettinger J, Nicke A (2012)
Involvement of the cysteine-rich “head” domain in activation and desensitization of the P2X1 receptor
Proc. Natl. Acad. Sci. USA, 109, 11396-11401
Beissner M*, Dutertre S*, Schemm R*, Danker T, Sporning A, Nicke A (2012)
Efficient binding of 4/7 -conotoxins to nicotinic 42 receptors is prevented by R185 and P195 in the 4 subunit
Mol. Pharmacol. 82, 711-718
Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse AH, Haag F, Adriouch S, Koch Nolte F (2012)
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation
PLoS ONE 7:e41269
Kendel Y, Melaun C, Kurz A, Nicke A, Peigneur S, Tytgat J, Wunder C, Mebs D, Kauferstein S. (2013)
Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors.
Toxins (Basel) 5:1043-50
Bhargava Y, Nicke A, Rettinger J. (2013)
Validation of Alexa-647-ATP as a powerful tool to study P2X receptor ligand binding and desensitization.
Biochem Biophys Res Commun. 438:295-300
Hempel, C, Nörenberg W, Sobottka H, Urban N, Nicke A, Fischer W, Schaefer M (2013)
The phenothiazine-class antipsychotic drugs prochlorperazine and trifluoperazine are potent allosteric modulators of the human P2X7 receptor.
Neuropharmacology 75C:365-379
Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A. (2018)
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.
Elife in press doi: 10.7554/eLife.36217
Giribaldi J, Wilson D, Nicke A, El Hamdaoui Y, Laconde G, Faucherre A, Moha Ou Maati H, Daly NL, Enjalbal C, Dutertre S. (2018)
Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom of Conus catus.
Toxins (Basel) in press doi: 10.3390/toxins10060222.
Leffler AE, Kuryatov A, Zebroski HA, Powell SR, Filipenko P, Hussein AK, Gorson J, Heizmann A, Lyskov S, Tsien RW, Poget SF, Nicke A, Lindstrom J, Rudy B, Bonneau R, Holford M. (2017)
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
Proc Natl Acad Sci U S A. 114(38):E8100-E8109
Kaczmarek-Hajek K*, Zhang J*, Kopp R*, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A (2018)
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.
eLife 7:e36217
El Hamdaoui Y, Wu X, Clark R, Garibaldi J, Anangi R, Craik D, King G, Dutertre S, Kaas Q, Herzig V, Nicke A (2019)
Structural and functional analysis of E. coli-expressed 4/7 -conotoxin TxIA analogues reveals preferential formation of ribbon isomers
Fron. Pharmacol. 10:577
Wilting F, Kopp R, Gurnev PA, Schedel A, Dupper NJ, Kwon O, Nicke A, Gudermann T, Schredelseker J (2020)
The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca2+ uptake.
Br J Pharmacol. 177:2947-2958
Wilson DT, Bansal PS, Carter DA, Vetter I, Nicke A, Dutertre S, Daly NL (2020)
Characterisation of a Novel A-Superfamily Conotoxin.
Biomedicines. 8:128
Morgan J, Alves M, Conte G, Menéndez-Méndez A, de Diego-Garcia L, de Leo G, Beamer E, Smith J, Nicke A, Engel T (2020)
Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse.
Neurosci Bull. 36:1242-1258
Pournara D, Durner A, Kritsi E, Papakostas A, Zoumpoulakis P, Nicke A, Koufaki M (2020)
Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists.
ChemMedChem. 15:2530-2543
Conte G, Nguyen NT, Alves M, de Diego-Garcia L, Kenny A, Nicke A, Henshall DC, Jimenez-Mateos EM, Engel T (2020)
P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice.
Front Mol Neurosci. 13:127
Giribaldi J*, Haufe Y*, Evans ERJ, Amar M, Durner A, Schmidt C, Faucherre A, Moha Ou Maati H, Enjalbal C, Molgó J, Servent D, Wilson DT, Daly NL, Nicke A, Dutertre S (2020)
Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors.
J Med Chem. 12;63:12682-12692
Ramírez-Fernández A, Urbina-Treviño L, Conte G, Alves M, Rissiek B, Durner A, Scalbert N, Zhang J, Magnus T, Koch-Nolte F, Plesnila N, Deussing JM, Engel T, Kopp R, Nicke A (2020)
Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model.
Sci Rep. 10:19876
Calovi S, Mut-Arbona P, Tod P, Iring A, Nicke A, Mato S, Vizi ES, Tønnesen J, Sperlagh B (2020)
P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia.
Front Mol Neurosci. 13:566251
Nevin ST, Lawrence N, Nicke A, Lewis RJ, Adams DJ (2020)
Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits.
Channels (Austin). 15:79-93
Er-Lukowiak M, Duan Y, Rassendren F, Ulmann L, Nicke A, Ufer F, Friese MA, Koch-Nolte F, Magnus T, Rissiek B (2020)
A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice.
iScience. 23:101870
Calzaferri F, Narros-Fernández P, de Pascual R, de Diego AMG, Nicke A, Egea J, García AG, de Los Ríos C (2021)
Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation.
J Med Chem64:2272-2290
Prades S, Heard G, Gale JE, Engel T, Kopp R, Nicke A, Smith KE, Jagger DJ (2021)
Functional P2X7 receptors in the auditory nerve of hearing rodents localize exclusively to peripheral glia.
J Neurosci. 2021 Feb 8:JN-RM-2240-20
Giribald J, Haufe Y, Evans ERJ, Wilson, DT, Daly NL, Enjalbal C, Nicke A, Dutertre S (2021)
Synthesis, structural and pharmacological characterizations of CIC, a novel α-conotoxin with an extended N-terminal tail
Marine Drugs (in press)
Übersichtsarbeiten
Nicke A, Rettinger J, Büttner C, Eichele A, Lambrecht G, Schmalzing G (1999)
Evolving view of quaternary structures of ligand-gated ion channels.
Progr. Brain Res, 120:61-80
Nicke A (2004)
Learning about structure and function of neuronal nicotinic acetylcholine receptors. Lessons from snails (Introduction to mini review series)
Eur. J. Biochem, 271:2293
Nicke A, Wonnacott S, Lewis RJ (2004)
-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes.
Eur. J. Biochem, 271:2305-19
Kaczmarek-Hájek K, Lörinczi E, Hausmann R, Nicke A (2012)
Molecular and functional properties of P2X receptors – recent progress and persisting challenges.
Purinergic Signal. 8:375-417
Saul A, Hausmann R, Kless A, Nicke A (2013)
Heteromeric assembly of P2X subunits
Front. Cell. Neurosci. 7, 250-250
Dutertre S, Nicke A, Tsetlin VI. (2017)
Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms.
Neuropharmacology 127:196-223
Jimenez-Mateos EM, Smith J, Nicke A, Engel T (2018)
Regulation of P2X7 receptor expression in the brain
Brain Res. Bull. 151:153
Kopp R, Krautloher A, Ramirez-Fernandez A, Nicke A (2019)
P2X7 interactions and signaling - making head or tail of it
Front. Mol. Neurosci.12:183
Nicke A, Ulens C, Rolland JF, Tsetlin VI (2020)
Editorial: From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design.
Front Pharmacol. 11:548366
Illes P, Müller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ, Kennedy C, Schmalzing G, Jarvis MF, Stojilkovic SS, King BF, Di Virgilio F (2020)
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.
Br J Pharmacol. 178:489-514
Engel T, Nicke A, Deussing J, Sperlagh B, Diaz-Hernandez M (2021)
Editorial: The P2X7 receptor as a common therapeutic target in brain diseases
Front Mol Neurosci. (in press)
Buchkapitel
Nicke A, King BF (2006)
Heteromerization of P2X receptors
In „Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies“ edited by Hugo R. Arias. Research Signpost. Trivandrum, India, 383-417
Nicke A, Grutter T, Egan T (2018)
P2X Receptors
In "The Oxford Handbook of Neuronal Ion Channels" edited by Arin Bhattacharjee. New York: Oxford University Press.