Walther-Straub-Institut für Pharmakologie und Toxikologie
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Original works:

Mittermeier L, Demirkhanyan L, Stadlbauer B, Breit A, Recordati C, Hilgendorff A, Matsushita M, Braun A, Simmons DG, Zakharian E, Gudermann T, Chubanov V. TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival. Proc Natl Acad Sci U S A, 2019. In press.

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Arterioscler Thromb Vasc Biol. 2018; 38: 344-352.

Gotru SK, Gil-Pulido J, Beyersdorf N, Diefenbach A, Becker IC, Vogtle T, Remer K, Chubanov V, Gudermann T, Hermanns HM, Nieswandt B, Kerkau T, Zernecke A. Braun A. Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. J Immunol; 2018. 200(8): 2529-2534.

Ferioli S, Zierler S, Zaisserer J, Schredelseker J, Gudermann T, Chubanov V. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg.ATP. Sci Rep. 2017; 7(1): 8806.

Pyrski M, Eckstein E, Schmid A, Bufe B, Weiss J, Chubanov V, Boehm U, Zufall F. Trpm5 expression in the olfactory epithelium. Mol Cell Neurosci. 2017; 80: 75-88.

Romagnani, A., V. Vettore, T. Rezzonico-Jost, S. Hampe, E. Rottoli, W. Nadolni, M. Perotti, M. A. Meier, C. Hermanns, S. Geiger, G. Wennemuth, C. Recordati, M. Matsushita, S. Muehlich, M. Proietti, Chubanov V, Gudermann T, Grassi F, Zierler S. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Nat Commun. 2017; 8(1): 1917.

Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife, 2016. 5

Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. Nat Commun, 2016; 7: 11097

Norenberg W, Plotz T, Sobottka H, Chubanov V, Mittermeier L, Kalwa H, Aigner A, Schaefer M. TRPM7 is a molecular substrate of ATP-evoked P2X7-like currents in tumor cells. J Gen Physiol, 2016; 147(6): 467-483.

Schafer S, Ferioli S, Hofmann T, Zierler S, Gudermann T, Chubanov V. Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. Pflugers Arch, 2016; 468(4): 623-634

Deckmann K, Krasteva-Christ G, Rafiq A, Herden C, Wichmann J, Knauf S, Nassenstein C, Grevelding CG, Dorresteijn A, Chubanov V, Gudermann, Bschleipfer T, Kummer W. Cholinergic urethral brush cells are widespread throughout placental mammals. Int Immunopharmacol. 2015; 29(1): 51-56.

Khatibi Shahidi M, Krivanek J, Kaukua N, Ernfors P, Hladik L, Kostal V, Masich S, Hampl A, Chubanov V, Gudermann T, Romanov RA, Harkany T, Adameyko I, Fried K.Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts. J Dent Res, 2015; 94 (7): 945-954.

Krasteva-Christ G, Soultanova A, Schutz B, Papadakis T, Weiss C, Deckmann K, Chubanov V, Gudermann T, Voigt A, Meyerhof M, Boehm U, Weihe E, and Kummer K. Identification of cholinergic chemosensory cells in mouse tracheal and laryngeal glandular ducts. Int Immunopharmacol, 2015; 29(1): 158-165.

Schutz B, Jurastow I, Bader S, Ringer C, Engelhardt J, Chubanov V, Gudermann T, Diener M, Kummer W, Krasteva-Christ G, Weihe E. Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract. Front Physiol, 2015; 6: 87.

Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W. Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131. Int Immunopharmacol, 2015; 29(1): 143-147.

Wiederhold S, Papadakis T, Chubanov V, Gudermann T, Krasteva-Christ G, Kummer W. A novel cholinergic epithelial cell with chemosensory traits in the murine conjunctiva. Int Immunopharmacol, 2015; 29(1): 45-50.

Panneck AR, Rafiq A, Schutz B, Soultanova A, Deckmann K, Chubanov V, Gudermann T, Weihe E, Krasteva-Christ G, Grau V, Rey A, Kummer W. Cholinergic epithelial cell with chemosensory traits in murine thymic medulla. Cell Tissue Res, 2014; 358(3): 737-748.

Ryazanova LV, Hu Z, Suzuki S, Chubanov V, Fleig A, Ryazanov AG. Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice. Sci Rep, 2014; 4: 7599.

Deckmann K, Filipskia K., Krasteva-Christa G, Froniusc M, Althausd M, Rafiqa A, Papadakisa T, Rennoa L, Jurastowa I, Wesselsa L, Wolffa M, Schütze B, Weiheb E, Chubanov V, Gudermannb T, Kleing J, Bschleipferh T, Kummer W. Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes Proc Natl Acad Sci U S A. 2014, May 19

Hofmann T, Schäfer S, Linseisen M, Sytik L, Gudermann T, Chubanov V Activation of TRPM7 channels by small molecules under physiological conditions. Pflügers Archiv 2014; Mar 15.

Eberle JA, Müller-Roth KL, Widmayer P, Chubanov V, Gudermann T, Breer H. Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa. Front Physiol. 2013; 4:182.

Eberle JA, Richter P, Widmayer P, Chubanov V, Gudermann T, Breer H. Band-like arrangement of taste-like sensory cells at the gastric groove: evidence for paracrine communication. Front Physiol. 2013; 4:58.

Krasteva G, Hartmann P, Papadakis T, Bodenbenner M, Wessels L, Weihe E, Schütz B, Langheinrich AC, Chubanov V, Gudermann T, Ibanez-Tallon I, Kummer W. Cholinergic chemosensory cells in the auditory tube. Histochem Cell Biol. 2012 137(4):483-97.

Chubanov V, Mederos Y Schnitzler M, Meißner M, Schäfer S, Abstiens K, Hofmann T, Gudermann T. Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7. Br J Pharmacol. 2012, 166(4):1357-76.

Krasteva G, Hartmann P, Papadakis T, Bodenbenner M, Wessels L, Weihe E, Schütz B, Langheinrich AC, Chubanov V, Gudermann T, Ibanez-Tallon I, Kummer W. Cholinergic chemosensory cells in the auditory tube. Histochem Cell Biol. 2012, 137(4):483-97.

Mederos y Schnitzler M, Wäring J, Gudermann T, and Chubanov V. Evolutionary determinants of divergent calcium selectivity of TRPM channels. FASEB J. 2008, 22(5):1540-51.

Roelle S, Grosse R, Büch T, Chubanov V, and Gudermann T. Essential role of Ca2+-acivated Pyk2/Src complex formation for neuropeptide-induced proliferation of small cell lung cancer cells. Oncogene. 2008, 27(12):1737-48

Kaske S, Krasteva G, König P, Kummer W, Hofmann T, Gudermann T, and Chubanov V. TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. BMC Neuroscience. 2007, (8):49.

Chubanov V, Schlingmann KP, Wäring J, Mederos y Schnitzler M, Waldegger S, and Gudermann T. Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6. J Biol Chem. 2007 (282):7656-67.

Butscheid Y, Chubanov V, Steger K, Dietrich A, and Gudermann T. Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Mol. Reprod. Dev. 2006 (3):350-60.

Touyz RM, He Y, Montezano AC, Yao G, Chubanov V, Gudermann T, and Calerra GE. Differential regulation of TRPM6/7 cation channels by Ang II in vascular smooth muscle cells from spontaneously hypertensive rats. Am. J. Physiol. 2006 (290): R73-R78.

Chubanov V, Waldegger S, Mederos y Schnitzler M, Vitzthum H, Sassen MC, Seyberth HW, Konrad M, and Gudermann T. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc Natl Acad Sci U S A. 2004; 10(9): 2894-9.

Hofmann T, Chubanov V, Gudermann T, and Montell C. TRPM5 is a voltage-modulated and Ca2+-activated monovalent selective cation channel. Curr Biol. 2003; 13(13): 1153-8.

Biebermann H, Krude H, Elsner A, Chubanov V, Gudermann T, and Gruters A. Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. Diabetes. 2003; 52(12): 2984-8.

Fedorovich SV, Chubanov V, Sholukh MV, and Konev SV. Influence of plasma membrane depolarization on cAMP level in rat brain synaptosomes. Neuroreport. 1999; 10(8):1763-5.

Chubanov V, Rogov IuI, Konoplia EF, and Sholukh MV. Functional interactions of components of the adenylate cyclase system in the rat liver after prenatal exposure to gamma irradiation. Radiats Biol Radioecol. 1999; 39 (4): 394-8.

Chubanov V, Rogov IuI, Sholukh MV, and Konoplia EF. Effect of prenatal gamma-irradiation on functional properties of rat liver adenylate cyclase. Vopr Med Khim. 1998; 44(2):145-50.

Reviews/Book chapters:

Chubanov V, Mittermeier L, Gudermann T. TRPM7 reflected in Cryo-EMirror. Cell Calcium. 2018; 76: 129-131.

Stangl MK, Bocker W, Chubanov V, Ferrari U, Fischereder M, Gudermann T, Hesse E, Meinke P, Reincke M, Reisch N, Saller MM, Seissler J, Schmidmaier R, Schoser B, Then C, Thorand B, Drey M. Sarcopenia - Endocrinological and Neurological Aspects. Exp Clin Endocrinol Diabetes. 2019; 127(1): 8-22.

Chubanov V, Mittermeier L, Gudermann T. Role of kinase-coupled TRP channels in mineral homeostasis. Pharmacol Ther. 2018; 184: 159-176.

Chubanov V, Kubanek S, Fiedler S, Mittermeier L, Gudermann T, Dietrich A. Renal Functions of TRP Channels in Health and Disease. Neurobiology of TRP Channels. nd and T. L. R. Emir. Boca Raton (FL). 2017; 187-212.

Chubanov V, Ferioli S, Gudermann T. Assessment of TRPM7 functions by drug-like small molecules. Cell Calcium. 2017; 67: 166-173.

Chubanov V, Schäfer S, Ferioli S, Gudermann T. Natural and Synthetic Modulators of the TRPM7 Channel. Cells, 2014; 3(4):1089-101.

Chubanov V and Gudermann T. TRPM6. Handbook of Experimental Pharmacology. 2014, 222:521-46.

Fleig A and Chubanov V. TRPM7. Handbook of Experimental Pharmacology. 2014, 222:521-46.

Chubanov V, Eggenschwiler J, Gudermann T, and Ryazanov A. The emerging role of TRPM7 in the regulation of magnesium homeostasis. Chapter in ‘TRP Channels in Drug Discovery’. Methods in Pharmacology and Toxicology. 2012, 222:503-20.

Paravicini TM, Chubanov V, Gudermann T. TRPM7: a unique channel involved in magnesium homeostasis. Int J Biochem Cell Biol. 2012, 44(8):1381-4

Dietrich A, Chubanov V, Gudermann T. Renal TRPathies. J Am Soc Nephrol. 2010, 21(5): 736-44.

Gudermann T, and Chubanov V. TRPM6 UCSD-Nature Molecule Pages. 2007

Dietrich A., Chubanov V, Kalwa H, Rost BR, Gudermann T. Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther. 2006, 112: 744-60.

Schlingmann KP, Waldegger S, Konrad M, Chubanov V, and Gudermann T. TRPM6 and TRPM7 – gatekeepers of human magnesium metabolism. Biochim Biophys Acta. 2007, 1772 (8):813-21.

Chubanov V, Gudermann T, and Schlingmann KP Essential role of TRPM6 for epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch. 2005; 51(1):228-34.

Chubanov V, Mederos Y Schnitzler M, Waring J, Plank A, and Gudermann T. Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes. Naunyn Schmiedebergs Arch Pharmacol. 2005; 371(4):334-41.

Curriculum vitae