Walther-Straub-Institut für Pharmakologie und Toxikologie
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Ausgewählte Publikationen

10 most important publications

Peer-reviewed:

  1. Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T*, Mederos y Schnitzler M*. Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nat Commun 10:5784, 2019. *corresponding author
  2. Mittermeier L, Demirkhanyan L, Stadlbauer B, Breit A, Recordati C, Hilgendorff A, Matsushita M, Braun A, Simmons DG, Zakharian E, Gudermann T*, Chubanov V*. TRPM7 is the central gatekeeper of intestinal absorption essential for postnatal survival. Proc Natl Acad Sci USA 116:4706-4715, 2019. *corresponding authors
  3. Storch U, Forst AL, Pardatscher F, Erdogmus S, Philipp M, Gregoritza M, Mederos Y Schnitzler M, Gudermann T. Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. Proc Natl Acad Sci USA 114:E37-E46, 2017.
  4. Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti S, Chubanov V, Gudermann T, Grassi F, Zierler S. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Nat Commun, 8:1917, 2017.
  5. Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife pii: e20914, doi: 10.7554/eLife.20914, 2016.
  6. Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Defects in TRPM7 channel function result in deregulated thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture. Nat Commun 7:11097, doi: 10.1038/ncomms11097, 2016.
  7. Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T*, Ghofrani HA, Dietrich A*. Activation of TRPC6 channels is essential for lung ischemia-reperfusion-induced lung edema in mice. Nat Commun 3:649, 2012. *senior authors
  8. Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nürnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Müller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nürnberg P, Hildebrandt F. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 38:1397-1405, 2006.
  9. Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99:7461-7466, 2002.
  10. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRP6 and TRP3 channels by diacylglycerol. Nature 397:259-263, 1999.

(Selected) Books:

Geisslinger G, Menzel S, Gudermann T, Hinz B, Ruth P. Mutschler Arzneimittelwirkungen ¬ Pharmakologie, Klinische Pharmakologie, Toxikologie, 11. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 2019.

Complete list of publications

Currently 263 publications listed in PubMed

h-Index:

66 (Web of Science, Clarivate Analytics)
76 (Google Scholar)

 

  2. Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T*, Ghofrani HA, Dietrich A*. Activation of TRPC6 channels is essential for lung ischemia-reperfusion-induced lung edema in mice. Nat Commun 3:649, doi: 10.1038/ncomms1660, 2012. *senior authors
  3. Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, Gollasch M, Gudermann T. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J 27:3092-3103, 2008.
  4. Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, Olschewski A, Mederos y Schnitzler M, Ghofrani HA, Schermuly RT, Pinkenburg O, Seeger W, Grimminger F, Gudermann T. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc NatlAcadSci USA 103:19093-19098, 2006.
  5. Chubanov V, Waldegger S, Mederos y Schnitzler M, Vitzthum H, Sassen MC, Seyberth HW, Konrad M, Gudermann T. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc NatlAcadSci USA 101:2894-2899, 2004.
  6. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRP6 and TRP3 channels by diacylglycerol. Nature 397:259-263, 1999.

For further publications please refer to PubMed.